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first_imgAssistant Professor of Stem Cell and Regenerative Biology Fernando Camargo, Assistant Professor of Pathology at Harvard Medical School (HMS) Alexander Gimelbrant, and Sun Hur, assistant professor of biological chemistry and molecular pharmacology at HMS, have been named 2010 Pew Scholars in the biomedical sciences by the Pew Charitable Trusts.The Pew Scholars program enables scientists to take calculated risks, expand their research, and explore unanticipated leads. It provides $240,000 over four years.Camargo will study how tumor growth is inhibited in a tissue-wide context. Using a mouse model, Camargo and his team are determining whether mechanisms controlling tissue size act as critical regulators of tumor growth. Camargo’s research has focused studies on the Hippo pathway of genes to test this model. Using a range of molecular biological techniques and ribonucleic acid (RNA) interference screens, Camargo hopes to identify novel regulators of a signaling pathway known as the Hippo pathway and to then determine their role as tumor suppressor genes.Gimelbrant’s laboratory will investigate how establishment of cell identity can be determined by the choice of which allele, maternal or paternal, will be expressed in a given cell lineage. He and his team have shown that this type of allelic choice occurs with many hundreds of human genes, creating an extraordinary epigenetic diversity in cell populations, such as those in the immune and nervous system. Gimelbrant’s team uses and develops a variety of approaches, including allele-specific arrays and whole-transcriptome next-generation sequencing, in order to build a comprehensive map of allele-specific expression and the correlated chromatin states.  This effort is under way in both human and mouse cells to gain an insight into the evolutionary context of allelic silencing.Hur’s research focuses on how the immune system detects viruses. She studies how RNAs are protected by the immune system, while viral RNAs, those made by viruses, are attacked by the immune system. Both types of RNA are made of the same four molecules. Using a combination of structural and biochemical techniques with computational modeling, Hur will investigate how immune systems distinguish between these two types of RNA. Her work will lend insight on how to prevent autoimmune or inflammatory diseases such as type I diabetes, arthritis, and inflammatory bowel disease.To read the complete announcement.last_img read more

first_img If upheld, the possibility of several of Pep Guardiola’s top stars departing in search of Champions League football would be a devastating situation for the club. Earlier this month the Daily Mail claimed City will look to prevent that scenario from occurring for two of their brightest talents by offering them fresh terms after their upcoming round of 16 tie with Real Madrid. The article stated that midfield maestro Kevin de Bruyne and England forward Raheem Sterling would be offered increases on their £280,000 and £300,000 per week salaries respectively. Read Also:England stars shocked over Raheem Sterling’s axe Man City have made a point of tying down their top talents to long-term contracts while still having several years remaining, with Leroy Sane and John Stones their only players under the age of 30 to not have at least three years remaining on their current deals. FacebookTwitterWhatsAppEmail分享 The England man, who signed for City from Liverpool in a controversial transfer in 2015, is understood to be in discussions over an improved deal. Sterling, 25, is under contract at The Etihad until 2023, but Italian reporter Nicolo Shira claims talks are underway over extending that by 12 months and raising his wages. The winger, who penned a deal in November 2018 worth a reported £300,000 a week, is set to agree a new contract worth around £18.5m a year or £357,000 a week. Following breaches of the Financial Fair Play rules, the Citizens were handed a two-year ban from European competitions, though the club are hopeful of successfully appealing the decision.Advertisement Loading… Promoted ContentTop 10 Enemies Turned Friends in TVLittle Georgie Henley Has Grown Into A Beautiful Swan!Ever Thought Of Sleeping Next To Celebs? This Guy Will Show YouWho Is The Most Powerful Woman On Earth?7 Reasons It’s Better To Be A Vegan8 Things That Will Happen If An Asteroid Hits Earth11 Most Immersive Game To Play On Your Table Top6 Ridiculous Health Myths That Are Actually TrueThe 10 Best Secondary Education Systems In The World10 Risky Jobs Some Women DoCouples Who Celebrated Their Union In A Unique, Unforgettable WayCan Playing Too Many Video Games Hurt Your Body? Manchester City are in talks with Raheem Sterling over a new contract, according to a report.last_img read more