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first_imgToday, nine-piece funk powerhouse Turkuaz announced a new batch of Spring 2017 tour dates. The tour will cover uncharted territory for the band as the make their way through the South, stopping to headline the Easter Island Festival in Oklahoma and play Austin, TX’s Euphoria Festival alongside Pretty Lights, Chromeo, The Disco Biscuits, and more.  The run also features performances in at Wanee Festival in Live Oak, FL and wraps up with a two-night stand in New Orleans during Jazz Fest supporting moe. As was previously announced, after the main run the band will head to Red Rocks with Lettuce in early May, Bonnaroo in early June, and Northwest String Summit and Floyd Fest in July.In addition to sharing the new dates, the band has announced that rising L.A. instrumental trio Organ Freeman will be joining them for nearly 20 stops along the tour. With a potent funk sound and impressive musicianship, the addition of Organ Freeman adds an extra layer of excitement for the upcoming run of performances.You can check out a full list of dates below. For more information, or to purchase tickets for any of the shows, visit the band’s website.Turkuaz 2017 Tour Dates (* w/ Organ Freeman; ^ w/ moe.)03/02 Salt Lake City, UT: The State Room03/03 Las Vegas, NV: Beauty Bar03/04 Phoenix, AZ: McDowell Mountain03/06 Steamboat Springs, CO: Schmiggity’s03/07 Frisco, CO: Barkley Ballroom03/09 Durango, CO: Animas City Theatre03/10 Telluride, CO: Sheridan Opera House03/11 Santa Fe, NM: Skylight03/12 Taos, NM: Taos Mesa*03/15 Davenport, IA: Redstone Room*03/16 Urbana, IL: Canopy Club*03/17 Columbus, OH: Woodland Tavern03/18 Columbus, OH: Woodland Tavern03/19 Kalamazoo, MI: Bell’s Brewery*03/21 Morgantown, WV: Mainstage*03/23 Ithaca, NY: The Haunt*03/24 Lancaster, PA: Chameleon Club*03/25 Stroudsburg, PA: Sherman Theater*04/06 Kansas City, MO: Knuckleheads Saloon04/07 Keetonville, OK: Easter Island04/08 Dallas, TX: Curtain Club04/09 Austin, TX: Euphoria Festival04/12 Fayetteville, AR: George’s Majestic Lounge*04/13 St. Louis, MO: Ready Room*04/14 Lexington, KY: Cosmic Charlies*04/15 Bloomington, IN: The Bluebird*04/18 Chattanooga, TN: Revelry Room*04/19 Athens, GA: Georgia Theatre*04/20 Charleston, SC: The Pour House*04/21 Live Oak, FL: Wanee Festival04/25 Oxford, MS: The Lyric*04/26 Jackson, MS: Duling Hall*04/27 Birmingham, AL: Saturn*04/28 New Orleans, LA: Civic Theatre^04/29 New Orleans, LA: Civic^05/13 Morrison, CO: Red Rocks06/08 Manchester, TN: Bonnaroo Music Festival07/14 Noth Plains, OR: Northwest String Summit07/28 Floyd, VA: Floyd Fest07/29 Floyd, VA: Floyd Festlast_img read more

first_imgThe mitotic spindle, an apparatus that segregates chromosomes during cell division, may be more complex than the standard textbook picture suggests, according to researchers at the Harvard School of Engineering and Applied Sciences (SEAS).The findings, which result from quantitative measurements of the mitotic spindle, appear in the journal Cell.The researchers used a femtosecond laser to slice through the strands of the organelle and then performed a mathematical analysis to infer the microscopic structure of the spindle from its response to this damage.“We’ve been using this nanosurgery technique to understand the architecture and assembly of the spindle in a way that was never possible before,” says Eric Mazur, Balkanski Professor of Physics and Applied Physics at Harvard, who co-authored the study. “It’s very exciting.”The spindle, which is made of protein strands called microtubules, forms during cell division and segregates chromosomes into the daughter cells. It was previously unclear how microtubules are organized in the spindles of animal cells, and it was often assumed that the microtubules stretch along the length of the entire structure, pole to pole.Mazur and his colleagues demonstrated that the microtubules can begin to form throughout the spindle. They also vary in length, with the shortest ones close to the poles.“We wondered whether this size difference might result from a gradient of microtubule stabilization across the spindle, but it actually results from transport,” says lead author Jan Brugués, a postdoctoral fellow at SEAS. “The microtubules generally nucleate and grow from the center of the spindle, from which point they are transported towards the poles. They disassemble over the course of their life span, resulting in long, young microtubules close to the midline and older, short microtubules closer to the poles.”“This research provides concrete evidence for something that we’ve only been able to estimate until now,” Brugués adds.Mazur and Brugués worked with Daniel Needleman, assistant professor of applied physics and molecular and cellular biology at Harvard, and Valeria Nuzzo, a former postdoctoral fellow in Mazur’s lab at SEAS, to bring the tools of applied physics to bear on a biological question.The team used a femtosecond laser to make two small slices perpendicular to the plane of growth of the spindle apparatus in egg extracts of the frog species Xenopus laevis.They were then able to collect quantitative data on the reconstruction of the spindle following this disruption and precisely determine the length and polarity of individual microtubules. Observing the speed and extent of depolymerization (unraveling) of the spindle, the team worked backwards to compile a complete picture of the beginning and end points of each microtubule. Finally, additional experiments and a numerical model confirmed the role of transport.“The laser allowed us to make precise cuts and perform experiments that simply were not possible using previous techniques,” says Mazur.With further inquiries into spindle architecture, the researchers hope that scientists will one day have a complete understanding, and possibly even control over, the formation of the spindle.“Understanding the spindle means understanding cell division,” notes Brugués. “With a better understanding of how the spindle is supposed to operate, we have more hope of tackling the range of conditions — from cancer to birth defects — that result from disruptions to the cell cycle or from improper chromosomal segregation.”The research was supported by the National Science Foundation and by a fellowship from the Human Frontiers Science Program.For additional information, contact Caroline Perry at [email protected]last_img read more

first_img Related Economists say national testing, contact tracing could make huge difference For COVID-19, the difference between surviving and not surviving severe disease may be due to the quality, not the quantity, of the patients’ antibody development and response, suggests a new Cell paper published by Galit Alter, a member of the Ragon Institute of MGH, MIT and Harvard.The study, published in the journal Cell, used Alter’s systems serology approach to profile the antibody immune responses of 193 hospitalized COVID-19 patients, comparing responses from patients with moderate and severe disease and patients who passed away from COVID-19.While all patients developed antibodies against SARS-CoV-2, the way the antibodies developed, or evolved, differed between the three groups. For patients that didn’t survive the disease, the antibody response never fully evolved.“There was a significant defect in the development of IgG antibodies, which may be essential in the early control and elimination of the virus, ” Alter says. “Here, we were able to see the global impact of this defective IgG evolution, resulting in a compromised ability to promote essential viral clearing immune functions.”In a mature immune response, antibodies both block infection and direct the immune system to kill infected cells. To guide the killer immune response, antibodies attach to the Fc-receptor, a “docking site” specific to antibodies that is found on all immune cells. Without strong Fc-receptor binding, antibodies may fail to grab and destroy virus following infection. Infection detection ‘Viral history’ tool VirScan offers new insights into antibody response to SARS-CoV-2 Fauci, Farmer, and Kim discuss coronavirus lessons so far Vaccine close, but it likely won’t be a silver bullet What might COVID cost the U.S.? Try $16 trillion Compared to survivors, patients who passed from COVID-19 had antibodies that never fully developed the ability to strongly bind to Fc-receptors and therefore may not have been able to fully trigger immune killing activity.Alter’s group, led by Tomer Zohar, Carolin Loos, Stephanie Fischinger, and Caroline Atyeo, also found that survivors’ immune systems could recognize and target an area of the SARS-CoV-2 spike protein known as the S2 domain. The S2 domain is found in other coronaviruses that infect humans, so patients whose antibodies can target it may have pre-existing immunity to the S2 domain because of exposure to other, common coronaviruses.Patients with antibodies that can recognize S2 domains on different coronaviruses may be able to use this pre-existing immunity to generate killer antibodies faster and sooner following SARS-CoV-2 infection.“If we can further understand the importance of cross-coronavirus immunity,” says Zohar, “researchers may be able to design vaccines able to counteract a much broader range of coronaviruses.”With studies like these, Alter and her team are working to understand the nature of protective immunity against SARS-CoV-2, including partnering with COVID-19 vaccine developers, to help bring an end to this pandemic.last_img read more

first_imgSaint Mary’s has experienced 12 bicycle thefts since August, David Gariepy, director of security said. Gariepy notified students of the thefts via e-mail Nov. 22. The e-mail, which stated thefts usually occurred near resident hall bicycle racks, encouraged students to report suspicious activity to campus security, especially “anyone near our bicycle racks, not fitting the description of a typical Saint Mary’s College student (female, late teens to early 20’s) should be viewed as suspicious.” Gariepy said more bicycles have been stolen than in previous years — “an unusually high number,” he said. Some of the thefts occurred to bicycles that were locked to the racks, Gariepy said. “Some bicycles were locked to bicycle racks and the locks were cut, while some bikes were not locked and simply taken,” he said. “Most were taken from or near bike racks located near our resident halls.” The e-mail said the bicycle locks, which were cut, were discarded where the bicycle was parked. Gariepy said campus security currently has no leads to particular suspects, but has been carefully watching for suspicious activity to prevent further thefts. “Officers are aware of the thefts and are keeping a closer watch for suspicious activity near bicycle storage areas,” he said. According to Gariepy, one bicycle was stolen in August, three in September, four in October and four in November. Gariepy encouraged students to make sure their bicycles were secured. He said students could prevent theft by registering their bicycles with campus security and purchasing tamper-proof locks to secure the bicycle to the rack. “Student may also take advantage of the indoor winter storage that security provides at no cost,” he said. Gariepy also reminded students to “be aware of suspicious persons or activity on campus and always report your observations to security.” To report suspicious activity at Saint Mary’s College, call campus security at 574-284-5000.last_img read more

first_imgJosé E. Limón, one of the country´s foremost scholars of Latino literature, has been named director of Notre Dame´s Institute for Latino Studies (ILS), the University announced in a press release Tuesday. As director, he will hold the Julian Samora Chair in Latino Studies. Timothy Matovina, an expert on Latino Catholicism, will serve as executive director of the institute, which is part of the College of Arts and Letters. Both appointments take effect July 1. “I am extraordinarily pleased and grateful for the opportunity to lead the Institute for Latino Studies to even greater prominence and to place it at the center of the intellectual life at Notre Dame,” Limón said in the release. “I look forward to working with Executive Director Timothy Matovina as well as the College of Arts and Letters and its departmental chairs.” “I look forward to working with my colleague José Limón to build on the strong foundation that Gilberto Cárdenas has laid at the Institute for Latino Studies,” Matovina said. Limón is the Notre Dame Professor of American Literature in the Department of English. He has authored three major books in the field of Latino studies: “American Encounters: Greater Mexico, the United States and the Erotics of Culture,” “Dancing with the Devil: Society and Cultural Poetics in Mexican-American South Texas” and “Mexican Ballads, Chicano Poems: History and Influence in Mexican-American Social Poetry.” The University of Texas Press will publish his fourth book, “Américo Paredes: Culture and Critique,” in fall 2012, according to the release. Limón teaches and writes on the literature of the American South. His academic interests include cultural studies, Latino literature, anthropology and literature, Mexicans in the United States, U.S.-Mexico cultural relations, critical theory, folklore and popular culture. Matovina, a professor of theology, is completing a 10-year term as director of the College’s Cushwa Center for the Study of American Catholicism. His new book, “Latino Catholicism: Transformation in America’s Largest Church,” published by Princeton University Press, analyzes the five-century-long history of Latino Catholics in America and how that history has affected them and their Church. Arts and Letters Dean John McGreevy said Cárdenas led ILS commendably since its creation in 1999. Cárdenas is a distinguished scholar of Mexican immigration and Latino art and serves as an assistant provost and sociology professor. “Gil Cardenas’s achievement is to place Notre Dame at the center of Latino studies in the U.S. through his visionary leadership of multiple programs, in fields as diverse as Latino health, immigration and Latino art,” McGreevy said. “We are deeply grateful for his efforts.” Latino studies is a key element of the academic mission of both the College and the University, McGreevy said. “The stakes for Notre Dame in Latino studies are unusually high. Latinos are already a central part of American culture, business and politics, and this influence – important for all Americans, not just Latinos – will only grow in coming decades,” he said in the release. “At the same time, Latinos will soon number half of American Catholics, a development reflected in Notre Dame’s rapidly growing number of Latino students. I look forward to working with two eminent scholars … in helping us to become preeminent in this area.last_img read more

first_imgShare:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window) JAMESTOWN – A new scavenger hunt is seeking to raise awareness about stopping the spread of Coronavirus in the Jamestown area.Known as the Harry the Hygiene Hound Children’s Scavenger Hunt, the campaign takes place outside of 50 businesses located throughout Jamestown and Lakewood area.Launched last week, the brainchild of Jamestown resident Rebecca Rosen calls on kids 14-years-old and younger equipped with mask and gloves to find hygiene reminders posted around the community.Rosen says local artist Gary Peters helped create the mascot. “I had the concept of Harry the Hygiene Hound, I knew what he wanted to look like, but, I am not an artist by anyway, shape or form,” explained Rosen. “So I contacted Gary, because he does wonderful murals for the Lucille Ball Desi Arnaz Center, and I asked him if he would like to become involved in helping the community during the pandemic, and he stepped right up to the plate.”The signs, remind everyone to wash their hands, stay six feet apart, tell someone if they are sick and remind them not to touch their face.Once contestants find all the locations, they’re asked to email them to Harry with their name, address and phone number to [email protected] total, there is $200 worth of prizes donated by local businesses. The contest ends on Friday.Rosen also thanks the Jamestown and Lakewood Mayor’s office, and the 50 businesses, for helping launch the campaign.last_img read more

first_img Sophie Okonedo Related Shows View Comments A starry revival of Arthur Miller’s The Crucible begins performances on March 1. Directed by Ivo van Hove, whose work was last seen on Broadway in Miller’s A View From the Bridge, The Crucible officially opens on March 31 at the Walter Kerr Theatre.The cast will also include Olivier nominee Ben Whishaw, Tony winner Sophie Okonedo, Oscar nominee Saoirse Ronan, Ciaran Hinds, Bill Camp, Jason Butler Harner, Tavi Gevinson and Tony winner Jim Norton.Set during the Salem witch trials of the 1690s, The Crucible is a timeless parable of morality, a scorching indictment of intolerance, and is a central work in the canon of American drama.This revival marks the third time Miller’s Tony Award-winning play graces the Main Stem stage. Arthur Miller’s The Crucible. Star Files Show Closed This production ended its run on July 17, 2016 Saoirse Ronan Ben Whishawlast_img read more

first_img View Comments Julianne Hough & Aaron Tveit in ‘Grease Live'(Photo: Kevin Estrada/FOX) The Creative Arts Emmy Awards were held on September 10 and 11, and the stage got a lot of love on the small screen. The live telecasts of Grease and The Wiz took home trophies, as did a Tony winner turned late night host and two Broadway alums in guest performances.Fox and Paramount Television’s Grease: Live won four awards: Outstanding Special Class Program, Technical Direction, Production Design (for Tony nominee David Korins) and Lighting Design and Direction. Paul Tazewell, who won a Tony Award earlier this year for Hamilton’s costume design, won for his work on NBC’s The Wiz Live!The Guest Actor awards for both Drama and Comedy went to Broadway alums. Tony nominee Hank Azaria won for Ray Donovan, and Peter Scolari, who can currently be seen in Wicked, was awarded for his work on Girls. The latter was a late addition to the nominee roster, replacing Peter MacNicol who was ruled ineligible.The Late Late Show with James Corden won for Interactive Program, and the Tony winner received an additional award in the Variety Special for the show’s Carpool Karaoke primetime special.Two series with a theatrical sensibility were awarded, as well. The CW comedy Crazy Ex-Girlfriend earned trophies for Single-Camera Picture Editing and Choreography, while the orchestra-centered Mozart in the Jungle picked up an award for Sound Mixing.The Primetime Emmy awards will be held on September 18. This year’s nominees include Tony winners Audra McDonald, Bryan Cranston, Liev Schreiber, Kevin Spacey, Viola Davis and Judith Light.last_img read more

first_img Colombian President Juan Manuel Santos declared a social and economic state of emergency, a constitutional mechanism that allows him to issue orders with the force of law in order to address the crisis originated by the intense rains that have left more than two hundred dead. “In order to confront extraordinary situations, we should also take extraordinary measures. We will take the decision to declare a disaster situation and an economic, social, and ecological emergency, as referred to in Article 215 of our Constitution,” Santos specified in an address broadcast on radio and television. According to the president, the state of emergency will have an initial duration of thirty days, with the possibility of extending it to ninety days, during which time “all necessary measures will be taken to respond to the emergency, both in the short term and in the medium and long terms.” “Initially, we will work on humanitarian aid, saving lives and providing shelter and food to the nearly 330,000 families that need it today,” Santos explained, without being more specific about these actions. He added that “afterward, we will turn to the rehabilitation phase to repair schools, roads, electricity grids, and other infrastructure that can be restored, and the third phase will be the reconstruction phase, which means building everything that may be destroyed or useless.” By Dialogo December 09, 2010last_img read more

first_imgDade County Bar works to help the mentally illAll the beauty and wealth in Miami-Dade County hides a growing population of people with untreated and often unknown mental illness, at a ratethree times the national average.The county has the highest percentage of people with mental illness in the United States approximately nine percent of the total county population or 180,000 residents. Nearly 800 inmates in the county jail have been diagnosed with serious mental illness, 500 of whom receive daily psychotropic medication, according to the Dade County Bar Association. The bar, under the leadership of President Ervin A. Gonzalez, has set out to help treat this burgeoning group of mentally ill.“Ridiculously large numbers of people with mental illness are not receiving treatment,” said Miami-Dade County Judge Steven Leifman, who spearheaded the effort on behalf of the court. “This is a public safety issue because people with mental illnesses are not getting treatment. Once they’re released, they’re back on the street committing new offenses and are recycled through the criminal justice system. This is costing taxpayers critical dollars. It costs almost $100 a day to keep someone with mental illness in jail.”In an April 19 set of resolutions, the Dade Bar urged the Florida Legislature “not to reduce mental health and substance abuse funding; to consider restoring and increasing funding for newer and more effective medications for people with serious and persistent mental illnesses who are served in community health centers, state hospitals, and the criminal justice system; and to consider funding intensive case management for defendants who are diverted from the criminal justice system to community mental health centers.”The resolution, an outgrowth of the Baker Act Subcommittee of the bar’s Probate and Guardianship Committee, was presented to the legislature’s appropriations committees in early April, said Johnnie Ridgely, executive director of the Dade County Bar Association.According to the resolution, the 11th Judicial Circuit is committed to improving the forensic mental health system by instituting a county court jail diversion program designed to divert misdemeanor defendants with mental illnesses to community mental health facilities within 24 hours after arrest, establishing a crisis intervention team police program in Miami Beach and Miami, and working to better identify mentally ill incarcerated defendants in an effort to provide expedited linkages for services and appropriate medication when needed.But to accomplish all the bar’s goals, the county needs more funding $2.5 million to be exact. The bar points to the success of such programs in other areas and notes that without increased funding, the recent changes will only have a limited effect in protecting the community.“I don’t think there is a lot of new money for these types of programs in the legislature,” said Judge Leifman. “It’ll be one of those cumulative effects next year I hope we’ll be more successful. A lot more people are paying attention to the issue because of what the bar has done.” Dade County Bar works to help the mentally ill June 15, 2001 Regular Newslast_img read more